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Filtered Search Results
eMolecules 881676-32-0 | 5-Bromo-1H-pyrrole-3-carbaldehyde | ChemScene | MFCD11875943 | 173.997 | C5H4BrNO | 98.000 | Brc1cc(C=O)c[nH]1 | 250mg | 536794765
5-Bromo-1H-pyrrole-3-carbaldehyde | ChemScene | 881676-32-0 | MFCD11875943 | 173.997 | C5H4BrNO | 98.000 | Brc1cc(C=O)c[nH]1 | 250mg | 536794765
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eMolecules 669013-00-7 | PEG3-Bis-nitrophenyl carbonate | Broadpharm | MFCD29079397 | 524.435 | C22H24N2O13 | 95.000 | [O-][N+](=O)c1ccc(OC(=O)OCCOCCOCCOCCOC(=O)Oc2ccc(cc2)[N+]([O-])=O)cc1 | 250mg | 298819277
PEG3-Bis-nitrophenyl carbonate | Broadpharm | 669013-00-7 | MFCD29079397 | 524.435 | C22H24N2O13 | 95.000 | [O-][N+](=O)c1ccc(OC(=O)OCCOCCOCCOCCOC(=O)Oc2ccc(cc2)[N+]([O-])=O)cc1 | 250mg | 298819277
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eMolecules 132187-16-7 | Ambeed | 2-[(4R)-45-Dihydro-4-(1-methylethyl)-2-oxazolyl]pyridine | 250mg | 600847192 | A756102 | 190.246 | C11H14N2O
Medchem Express | 23-Dihydroxyquinoxaline | 25mg | 761506532 | HY-20803 | 15804-19-0 | MFCD00006723 | 162.148 | C8H6N2O2
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eMolecules 1026201-45-5 | 8-Bromoimidazo[1,2-a]pyridine-2-carboxylic acid | Ambeed | MFCD12195903 | 241.044 | C8H5BrN2O2 | 95.000 | OC(=O)c1cn2cccc(Br)c2n1 | 100mg | 552709072
8-Bromoimidazo[1,2-a]pyridine-2-carboxylic acid | Ambeed | 1026201-45-5 | MFCD12195903 | 241.044 | C8H5BrN2O2 | 95.000 | OC(=O)c1cn2cccc(Br)c2n1 | 100mg | 552709072
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eMolecules 936-05-0 | Ambeed | (1-Methyl-5-nitro-1H-imidazol-2-yl)methanol | 1g | 524982981 | A100321 | MFCD00159675 | 157.129 | C5H7N3O3
Ambeed | (1-Methyl-5-nitro-1H-imidazol-2-yl)methanol | 1g | 524982981 | A100321 | 936-05-0 | MFCD00159675 | 157.129 | C5H7N3O3
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eMolecules 471915-89-6 | N-[2-(3,4-DIHYDROXYPHENYL)ETHYL]-2-METHYL-2-PROPENAMIDE | AstaTech | MFCD18816134 | 221.256 | C12H15NO3 | 95.000 | CC(=C)C(=O)NCCc1ccc(O)c(O)c1 | 0.25g | 448269271
N-[2-(3,4-DIHYDROXYPHENYL)ETHYL]-2-METHYL-2-PROPENAMIDE | AstaTech | 471915-89-6 | MFCD18816134 | 221.256 | C12H15NO3 | 95.000 | CC(=C)C(=O)NCCc1ccc(O)c(O)c1 | 0.25g | 448269271
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eMolecules 86393-33-1 | Fluoroquinolonic Acid | Ambeed | MFCD00792458 | 281.670 | C13H9ClFNO3 | 98.000 | OC(=O)c1cn(C2CC2)c2cc(Cl)c(F)cc2c1=O | 5g | 552561193
Fluoroquinolonic Acid | Ambeed | 86393-33-1 | MFCD00792458 | 281.670 | C13H9ClFNO3 | 98.000 | OC(=O)c1cn(C2CC2)c2cc(Cl)c(F)cc2c1=O | 5g | 552561193
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eMolecules 919106-89-1 | 3-methoxy-2-methylindazole-6-carboxylic acid | Synthonix | MFCD11655600 | 206.201 | C10H10N2O3 | 98.000 | COc1n(C)nc2cc(ccc12)C(O)=O | 250mg | 794075516
3-methoxy-2-methylindazole-6-carboxylic acid | Synthonix | 919106-89-1 | MFCD11655600 | 206.201 | C10H10N2O3 | 98.000 | COc1n(C)nc2cc(ccc12)C(O)=O | 250mg | 794075516
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eMolecules 478646-32-1 | (R)-Benzyl piperidin-3-ylcarbamate | Ambeed | MFCD04115318 | 234.299 | C13H18N2O2 | 97.000 | O=C(N[C@@H]1CCCNC1)OCc1ccccc1 | 100mg | 525098642
(R)-Benzyl piperidin-3-ylcarbamate | Ambeed | 478646-32-1 | MFCD04115318 | 234.299 | C13H18N2O2 | 97.000 | O=C(N[C@@H]1CCCNC1)OCc1ccccc1 | 100mg | 525098642
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eMolecules 74863-82-4 | 3-Methyl-8-quinolinesulphonyl chloride | Ambeed | MFCD02683367 | 241.690 | C10H8ClNO2S | 95.000 | Cc1cnc2c(cccc2c1)S(Cl)(=O)=O | 1g | 491676924
3-Methyl-8-quinolinesulphonyl chloride | Ambeed | 74863-82-4 | MFCD02683367 | 241.690 | C10H8ClNO2S | 95.000 | Cc1cnc2c(cccc2c1)S(Cl)(=O)=O | 1g | 491676924
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eMolecules 944902-07-2 | 6-CHLORO-2-METHOXYPYRIMIDINE-4-CARBOXYLIC ACID | AstaTech | MFCD10697050 | 188.570 | C6H5ClN2O3 | 95.000 | COc1nc(Cl)cc(n1)C(O)=O | 0.1g | 784435663
6-CHLORO-2-METHOXYPYRIMIDINE-4-CARBOXYLIC ACID | AstaTech | 944902-07-2 | MFCD10697050 | 188.570 | C6H5ClN2O3 | 95.000 | COc1nc(Cl)cc(n1)C(O)=O | 0.1g | 784435663
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eMolecules 2230887-26-8 | Ambeed | 444-(Pyridine-246-triyl)tribenzaldehyde | 100mg | 633659406 | A1164710 | 391.426 | C26H17NO3
Ambeed | Methyl 3-(4-chlorophenyl)propanoate | 1g | 572951392 | A390732 | 50561-69-8 | MFCD08273468 | 198.650 | C10H11ClO2
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eMolecules 1642-49-5 | ChemScene | 9-Decynoic acid | 100mg | 718356571 | CS-0143674 | MFCD08064029 | 168.236 | C10H16O2
Pharmablock | 1-fluoro-2-trifluoromethanesulfonylbenzene | 25mg | 551183616 | PBZX1568 | 2358-41-0 | MFCD09971596 | 228.160 | C7H4F4O2S
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Medchemexpress LLC ART558 | 2603528-97-6 | 99.97% | C21H21F3N4O2 | 100 MG
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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ART558 is a potent, selective, and allosteric DNA polymerase theta (Polθ) inhibitor with an IC50 of 7.9 nM. It elicits BRCA-gene synthetic lethality and DNA damage, making it suitable for cancer research, including breast cancer.
- Elicits BRCA-gene synthetic lethality and DNA damage.
- Inhibits Theta-Mediated End Joining without affecting Non-Homologous End Joining.
- Enhances the effects of a PARP inhibitor.
- Increases biomarkers of single-stranded DNA and synthetic lethality in 53BP1-defective cells.
- Prolongs the residence time of YFP-tagged full-length Polθ at sites of laser-induced DNA damage.
- Shows antiproliferative activity against human BRCA-2 deficient DLD-1 cells (EC50 = 0.8 nM).
- Inhibits microhomology-mediated end joining in HEK293 cells (EC50 = 180 nM).
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eMolecules 26311-45-5 | Ambeed | 4-Pentylbenzoic acid | 25g | 525882017 | A876426 | MFCD00002572 | 192.258 | C12H16O2
Ambeed | 24-Dichlorophenyl acetate | 1g | 660584852 | A635170 | 6341-97-5 | MFCD00276630 | 205.030 | C8H6Cl2O2
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